Multiple shRNA combinations for near-complete coverage of all HIV-1 strains
نویسندگان
چکیده
منابع مشابه
Multiple shRNA combinations for near-complete coverage of all HIV-1 strains
BACKGROUND Combinatorial RNA interference (co-RNAi) approaches are needed to account for viral variability in treating HIV-1 with RNAi, as single short hairpin RNAs (shRNA) are rapidly rendered ineffective by resistant strains. Current work suggests that 4 simultaneously expressed shRNAs may prevent the emergence of resistant strains. RESULTS In this study we assembled combinations of highly-...
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ژورنال
عنوان ژورنال: AIDS Research and Therapy
سال: 2011
ISSN: 1742-6405
DOI: 10.1186/1742-6405-8-1